Pyridines and derivatives
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- (1)
- (1)
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Filtered Search Results
Medchemexpress LLC Homologous recombination-IN-1 | 391889-85-3 | 98.7% | 485.96 | 5 MG
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Homologous recombination-IN-1 is a novel RAD51-BRCA2 protein-protein interaction inhibitor (EC50=19 μM) that can interfere with homologous recombination. It reduces cell homologous recombination in a dose-dependent manner at concentrations of 10-40 μM over 5 hours.
- Purity: 98.65%
- Molecular weight: 485.96
- Formula: C28H24ClN3O3
- CAS No.: 391889-85-3
- Appearance: Solid
- Color: Light yellow to yellow
- Storage for powder: -20°C for 3 years; 4°C for 2 years
- Storage in solvent: -80°C for 6 months; -20°C for 1 month
- In vitro solubility: DMSO at 50 mg/mL (102.89 mM)
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Medchemexpress LLC 8-aminoadenosine | 3868-33-5 | MFCD00047230 | 99.9% | 282.26 g/mol | C10H14N6O4 | 25MG
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8-Aminoadenosine is an RNA-directed adenosine nucleoside analogue used in biochemical and pharmacological research to reduce cellular ATP levels and inhibit mRNA synthesis. It is supplied as a white to off-white solid with a reported molecular formula of C10H14N6O4 and molecular weight of 282.26 g/mol. The compound is soluble in DMSO and requires appropriate cold storage for long-term stability.
- Reduces cellular ATP and inhibits mRNA synthesis.
- Applicable for studies of RNA metabolism and cell signaling.
- High reported purity (99.94%).
- White to off-white solid, suitable for powder handling.
- Soluble in DMSO; sonication may improve solubility.
- Stable when stored under recommended freezer conditions.
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Medchemexpress LLC Glutamate Receptor 1 (AMPA Subtype) Antibody (YA407) | 90 kDa | 100 UL
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Glutamate Receptor 1 (AMPA Subtype) Antibody is a rabbit-derived, non-conjugated IgG monoclonal antibody, specifically targeting Glutamate Receptor 1 (AMPA Subtype). This receptor acts as a ligand-gated cation channel, activated by L-glutamate and glutamatergic agonists. Crucial for central nervous system excitation, it converts chemical signals to electrical impulses by facilitating cation entry.
- Rabbit-derived IgG monoclonal antibody
- Targets glutamate receptor 1 (AMPA subtype)
- Observed molecular weight: 90 kDa
- Protein A affinity purified
- Liquid formulation
- Reacts with mouse and rat
- Applications: WB, IHC-P, IP
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![Medchemexpress LLC 7-methoxy-4-((6-phenyl-1,2,4-triazolo[4,3-b]pyridazin-3-yl)methoxy)quinoline | 1002304-34-8 | 99.9% | 50 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000233296.png-250.jpg)
Medchemexpress LLC 7-methoxy-4-((6-phenyl-1,2,4-triazolo[4,3-b]pyridazin-3-yl)methoxy)quinoline | 1002304-34-8 | 99.9% | 50 MG
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AMG-208 is an orally active small-molecule inhibitor of c-Met and RON tyrosine kinases used in preclinical cancer research. It demonstrates low-nanomolar biochemical potency against c-Met, cellular activity in cancer cell lines, and reported CYP3A4 inhibition. Supplied for laboratory research use only.
- Orally active c-Met and RON tyrosine kinase inhibitor
- Biochemical IC50 for c-Met ≈ 9 nM
- Cellular activity: inhibits c-Met autophosphorylation in prostate cancer cells (IC50 ≈ 46 nM)
- Reports CYP3A4 inhibition (IC50 ≈ 32 μM)
- High research-grade purity (≈99.9%)
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eMolecules 10465-81-3 | 1,1'-(Azodicarbonyl)dipiperidine | Oakwood Chemicals | MFCD00010111 | 252.318 | C12H20N4O2 | 97.000 | O=C(\N=N\C(=O)N1CCCCC1)N1CCCCC1 | 1g | 480160952
1,1'-(Azodicarbonyl)dipiperidine | Oakwood Chemicals | 10465-81-3 | MFCD00010111 | 252.318 | C12H20N4O2 | 97.000 | O=C(\N=N\C(=O)N1CCCCC1)N1CCCCC1 | 1g | 480160952
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eMolecules 10465-81-3 | 1,1'-(Azodicarbonyl)dipiperidine | Oakwood Chemicals | MFCD00010111 | 252.318 | C12H20N4O2 | 97.000 | O=C(\N=N\C(=O)N1CCCCC1)N1CCCCC1 | 5g | 480160953
1,1'-(Azodicarbonyl)dipiperidine | Oakwood Chemicals | 10465-81-3 | MFCD00010111 | 252.318 | C12H20N4O2 | 97.000 | O=C(\N=N\C(=O)N1CCCCC1)N1CCCCC1 | 5g | 480160953
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Medchemexpress LLC Mirodenafil | 862189-95-5 | 99.9% | 531.67 | 100 MG
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Mirodenafil (SK3530) is an orally active, potent, reversible, and selective phosphodiesterase 5 (PDE5) inhibitor. It also acts as a glucocorticoid receptor (GR) modulator and activates the Wnt/β-catenin signaling pathway by downregulating Dkk1 expression. Mirodenafil is used in research for erectile dysfunction (ED), Alzheimer's disease (AD), and systemic sclerosis (SSc).
- Orally active
- Potent, reversible, and selective PDE5 inhibitor
- Glucocorticoid receptor (GR) modulator
- Activates Wnt/β-catenin signaling pathway by downregulating Dkk1 expression
- Enhances neuronal survival by protecting mitochondrial membrane potential and inhibiting apoptosis
- Inhibits GSK-3β signaling, reducing tau phosphorylation and Aβ production
- Enhances cognitive-behavioral performance in transgenic AD mice
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Medchemexpress LLC NSC 194308 | 90379-42-3 | C12H22N2O3S2 | 25 MG
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NSC 194308 is an enhancer of U2AF2-RNA complexes, increasing the association of the U2AF1-U2AF2-SF1-splice site RNA complex by binding between the RRM1 and RRM2 motifs of U2AF2. This compound inhibits pre-mRNA splicing by stopping spliceosome assembly when U2AF recruits U2 snRNP to the branchpoint, and also enhances pre-mRNA binding to U2AF2, leading to selective cell death in leukemia cell lines with spliceosome mutations.
- Enhances U2AF2-RNA complexes
- Increases association of U2AF1-U2AF2-SF1-splice site RNA complex
- Binds between RRM1 and RRM2 motifs of U2AF2
- Inhibits pre-mRNA splicing by stalling spliceosome assembly
- Selectively triggers cell death in leukemia cell lines with spliceosome mutations
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Medchemexpress LLC CC214-1 | 1021920-32-0 | C20H21N7O2 | 25 MG
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CC214-1 is a potent mTOR inhibitor that induces autophagy, with an IC50 of 0.002 μM. This compound is useful as an in vitro tool for exploring mTOR kinase biology and for Glioblastoma studies.
- Potent mTOR inhibitor (IC50 of 0.002 μM)
- Induces autophagy
- Useful for exploring mTOR kinase biology in vitro
- Suitable for glioblastoma studies
- Inhibits mTORC2 (IC50 of 0.018 μM in PC-3 cells) and mTORC1 (IC50 of 0.04 μM in PC-3 cells)
- Synergizes with rapamycin to inhibit mTORC1 signaling and tumor cell proliferation
- Mediates sensitivity to growth arrest in glioblastoma cells
- Inhibits T cell activation and expression of activation markers
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Medchemexpress LLC SU056 | 2376580-08-2 | C20H16FNO5 | 100 MG
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SU056 is a YB-1 inhibitor. It induces cell-cycle arrest, apoptosis, and inhibits cell migration in ovarian cancer cells. It interacts with YB-1 and inhibits its associated downstream proteins and pathways. SU056 can enhance the cytotoxic effects of Paclitaxel.
- Induces cell-cycle arrest, apoptosis, and inhibits cell migration in ovarian cancer cells.
- Inhibits colony formation.
- Inhibits tumor growth in vivo.
- Enhances the cytotoxic effects of Paclitaxel.
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![Medchemexpress LLC [Des-Arg9]-Bradykinin acetate | 23827-91-0 | 99.9% | 964.07 | 50 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000425194.png-250.jpg)
Medchemexpress LLC [Des-Arg9]-Bradykinin acetate | 23827-91-0 | 99.9% | 964.07 | 50 MG
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[Des-Arg9]-Bradykinin acetate is a Bradykinin B1 receptor agonist that displays selectivity for B1 over B2 receptors. The B2 receptor is responsible for the actions of bradykinin (BK) and lysyl-bradykinin (Lys-BK), which are formed in response to injury from kininogen precursors. The B1 receptor, however, mediates the actions of [Des-Arg9]-Bradykinin (des-Arg9-BK) and Lys-des-Arg Arg9-BK, which are formed by carboxypeptidases acting on BK and Lys-BK. This product is for research use only.
- Bradykinin B1 receptor agonist
- Displays selectivity for B1 over B2 receptors
- Mediates actions of [Des-Arg9]-Bradykinin (des-Arg9-BK) and Lys-des-Arg Arg9-BK
- For research use only
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Medchemexpress LLC Cpi1 | 3085809-95-3 | 99.3% | 2299.43 | 1 MG
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CPI1 is a multidrug resistance protein 1 (MRP1) inhibitor with a Ki value of 100 nM. It functions by binding to the same substrate-binding site as leukotriene C4, which stabilizes MRP1 in an apo-like inward-facing conformation. This action blocks the necessary conformational changes for ATP hydrolysis and substrate transport, thereby inhibiting the ATPase activity of human and bovine MRP1. CPI1 is a valuable tool for investigating the substrate transport mechanism of MRP1 and is applicable to research concerning cancer multidrug resistance.
- Potent inhibitor of MRP1 with a Ki value of 100 nM.
- Inhibits both basal and leukotriene C4-stimulated ATPase activity of bovine MRP1.
- Serves as a research tool for understanding MRP1 substrate transport.
- Applicable to research concerning cancer multidrug resistance.
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Medchemexpress LLC MPSD control peptide (TFA) | 95.8% | 3192.80 | 1 MG
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MPSD control peptide (MARCKS-ED control peptide) is a control peptide for MPSD peptide (HY-P10471). This 25-amino acid peptide is based on the effector domain sequence of the intracellular membrane protein myristoylated alanine-rich C-kinase substrate (MARCKS). It can sense membrane curvature and recognize phosphatidylserine, making it useful as a biological probe to study membrane shape and lipid composition.
- Control peptide for MPSD peptide
- Composed of 25 amino acids
- Based on MARCKS effector domain sequence
- Senses membrane curvature
- Recognizes phosphatidylserine
- Utilized as a biological probe
- Formula: C151H243N41O35.xC2HF3O2
- Appearance: White to off-white solid
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Medchemexpress LLC Apitegromab 5mg | 5mg
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Apitegromab (SRK-015) is an anti-promyostatin monoclonal antibody Apitegromab can be used for the research of neuromuscular disease including spinal muscular atrophy[1][2]
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Medchemexpress LLC α-CGRP (mouse, rat) | 83651-90-5 | 99.8% | 3806.25 | 5 MG
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α-CGRP (mouse, rat) is a neuropeptide (calcitonin gene-related peptide (CGRP)) mainly expressed in the neuromuscular junction, acting as a potent vasodilator. It can lead to a fall in blood pressure, an increase in heart rate by peripheral administration, and relaxation of colonic smooth muscle. This peptide has potential in cardiovascular, pro-inflammatory, migraine, and metabolic studies.
- Regulates innate lymphoid cell response and insulin secretion.
- Decreases mean arterial blood pressure and increases heart rate in vivo.
- Plays a role in regulating Kainic acid (KA) induced pyramid-cell death in the hippocampal CA3 region.
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